Ergotamine types: As a result of the theoretical odds of ergotism, the new concurrent the means to access azithromycin which have ergot derivatives isn’t required (come across section 4.4).
In the event neutropenia might have been with the use of rifabutin, an effective causal link to combination which have azithromycin has not been oriented (look for Part cuatro
Caution is recommended throughout the co-management of these medication having Azithromycin from the understood boosting effect of such medication whenever put simultaneously for the macrolid antibiotic drug erythromycin.
Co-administration off atorvastatin (10 milligrams daily) and you will azithromycin (500 mg each day) did not alter the plasma levels from atorvastatin (according to an effective HMG CoA-reductase inhibition assay). But not, post-selling cases of rhabdomyolysis into the customers acquiring azithromycin which have statins enjoys come stated.
Into the a good pharmacokinetic communication data from inside the healthy volunteers, zero extreme impact is observed into plasma levels of carbamazepine or its active metabolite within the people finding concomitant azithromycin.
Even though a beneficial causal matchmaking was not created, planning are given to the fresh frequency off monitoring prothrombin date when azithromycin is employed in people getting coumarin-types of oral anticoagulants
Cisapride is metabolized throughout the liver by chemical CYP 3A4. Just like the macrolides restrict it enzyme, concomitant government regarding cisapride could potentially cause the rise of QT period prolongation, ventricular arrhythmias and you may torsades de pointes.
From inside the a great pharmacokinetic investigation investigating the consequences of just one amount out of cimetidine, considering couple of hours just before azithromycin, on the pharmacokinetics regarding azithromycin, zero customization off azithromycin pharmacokinetics is seen.
During the good pharmacokinetic communications study, azithromycin didn’t change the anticoagulant aftereffect of a single fifteen mg dose from warfarin given to help you healthy volunteers. There had been reports obtained from the article-product sales chronilogical age of potentiated anticoagulation after co-management out-of azithromycin and you can coumarin-particular dental anticoagulants.
In a pharmacokinetic study with healthy volunteers that were administered a 500 mg/day oral dose of azithromycin for 3 days and were then administered a single 10 mg/kg oral dose of cyclosporin, the resulting cyclosporin Cmaximum escort Kansas City and AUC0-5 were found to be significantly elevated. Consequently, caution should be exercised before considering concurrent administration of these drugs. If co-administration of these drugs is necessary, cyclosporin levels should be monitored and the dose adjusted accordingly.
Co-administration out-of an effective 600 milligrams solitary dose out-of azithromycin and you may eight hundred mg efavirenz each and every day to own 7 days don’t bring about people clinically significant pharmacokinetic affairs.
Co-administration of a single dose of 1200 mg azithromycin did not alter the pharmacokinetics of a single dose of 800 mg fluconazole. Total exposure and half-life of azithromycin were unchanged by the co-administration of fluconazole, however, a clinically insignificant decrease in Cmax (18%) of azithromycin was observed.
Co-administration of a single dose out-of 1200 mg azithromycin didn’t come with statistically high impact on this new pharmacokinetics of indinavir applied because 800 milligrams 3 times each day for five months.
Inside the match volunteers, co-management from azithromycin five hundred mg/big date for 3 days failed to cause clinically extreme changes in new pharmacokinetics and pharmacodynamics of a single fifteen milligrams dose of midazolam.
Co-administration from azithromycin (1200 mg) and nelfinavir on steady-state (750 mg 3 times every day) led to increased azithromycin concentrations. No medically tall adverse effects was in fact observed without amount improvement will become necessary.
In normal healthy male volunteers, there was no evidence of an effect of azithromycin (500 mg daily for 3 days) on the AUC and Cmax of sildenafil or its major circulating metabolite.
Pharmacokinetic studies have reported no proof a discussion anywhere between azithromycin and you may terfenadine. There are infrequent cases advertised where possibility of eg a connections could not end up being entirely excluded; not there was zero particular research that particularly an interacting with each other had occurred.